Status:
COMPLETED
The Role of Opioidergic Systems in Breathing Based Analgesia
Lead Sponsor:
University of California, San Diego
Conditions:
Pain
Eligibility:
All Genders
18-55 years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of this psychophysical and pharmacologic study is to determine if slow-breathing induced pain relief is mediated by endogenous opioids in response to intravenous (IV) administration of the...
Detailed Description
The proposed study will employ a graded analytical approach to compare mindfulness to placebo-meditation and a slow-breathing exercise in response to double-blind intravenous administration (IV) of na...
Eligibility Criteria
Inclusion
- Normal volunteers with no history of chronic pain problems
- Volunteers had no prior meditation experience
- Volunteers could be male and non-pregnant females.
- Volunteers of all ethnic backgrounds were included.
Exclusion
- Female volunteers could not be pregnant.
- They could not be taking opioids or antidepressants.
- Subjects with a repeated history of syncope, loss of consciousness, light headedness, nausea, dizziness, or vomiting in response to needles or blood could not participate in the study.
- Subject could not be using exogenous opiates for the complete duration of the study.
Key Trial Info
Start Date :
March 13 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 27 2017
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03419858
Start Date
March 13 2017
End Date
June 27 2017
Last Update
June 11 2019
Active Locations (1)
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1
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157