Status:
COMPLETED
Nitrous Oxide Added at the End of Sevoflurane Anesthesia and Recovery
Lead Sponsor:
General Hospital Zadar
Conditions:
Elective Surgical Procedures
Laparoscopy
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Addition of nitrous oxide N2O towards the end of prolonged isoflurane anesthesia hastens patients recovery. The hypothesis is that the addition of N2O at the end of prolonged sevoflurane anaesthesia a...
Detailed Description
The investigators will include 100 adult patients, American Society of Anesthesiologists (ASA) physical status I-III, who will be scheduled for elective laparotomies or laparoscopic surgeries under se...
Eligibility Criteria
Inclusion
- Adult patients, American Society of Anesthesiologists Physical status ASA PS I-III, scheduled for laparotomic and laparoscopic surgery expected to last 2 hours or more who can understand and signed informed consent.
Exclusion
- Patients who will be discharged within 72 hours after surgery
- Patients on intensive care within few months before the study enrollment
- Diseases that impair gastric motility (diabetes mellitus, chronic cholecystitis, gastric and intestinal disease, neuromuscular disorders, neuropathies, liver dysfunction)
- Vestibular disease; history of migraine headaches, central nervous system injury
- Renal impairment
- Patients on antihistamines, antipsychotics, contraceptives, steroids within 72 hours before surgery
- Known hypersensitivity to drugs used in the study protocol
- Alcoholism, and/or opioid addiction
- Conditions that can influence the incidence of PONV, postoperative pain or morbidity (e.g., significant intraoperative surgery complications), intraoperative drug allergy, severe intraoperative hypotension, perioperative hypoxia, excessive blood loss, difficult intubation
Key Trial Info
Start Date :
February 7 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 25 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03420586
Start Date
February 7 2018
End Date
July 25 2021
Last Update
November 9 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
General Hospital Zadar
Zadar, Croatia, 23000