Status:
COMPLETED
Comparative Study of the Change in Liver Enzymes After General or Spinal Anesthetic Techniques in Patients With Preoperatively Elevated Liver Enzymes.
Lead Sponsor:
Cairo University
Collaborating Sponsors:
Hala Mostafa Gomaa
Norhan Abdelaleem Ali
Conditions:
Liver Enzymes After General or Spinal Anesthetic Techniques
In Patients With Preoperatively Elevated Liver Enzymes
Eligibility:
All Genders
18-60 years
Brief Summary
* To assess the changes in liver functions postoperatively in patients with preoperatively elevated liver enzymes. * To identify the most appropriate anesthesia technique for patients with preoperativ...
Detailed Description
Surgery and anesthesia are stressful events, thus there is a possibility that liver enzymes and bilirubin may increase postoperatively. Mild elevations of serum aminotransferase, alkaline phosphatase,...
Eligibility Criteria
Inclusion
- Adult healthy ASA I, II patients, both genders, aged 18 - 60 years, with stationary elevated liver enzymes \< 2 folds undergoing elective lower abdominal wall or limb surgeries with expected operation time less than 2 hours
Exclusion
- ASA class III or IV
- Age \>60 years or \<18 years
- Patients undergoing intraperitoneal and laparoscopic procedures.
- Acute viral hepatitis: inflammation of the liver caused by infection with one of the five hepatitis viruses. In most people, the inflammation begins suddenly and lasts only a few weeks.
- Acute alcoholic hepatitis: is inflammation of the liver due to excessive intake of alcohol. It is usually found in association with fatty liver, an early stage of alcoholic liver disease, and may contribute to the progression of fibrosis, leading to cirrhosis.
- Severe chronic hepatitis: is inflammation of the liver that lasts at least 6 months.
- Child's C class classification: this score is used to assess the prognosis of chronic liver disease, mainly cirrhosis.
- Severe coagulopathy: a pathological condition that reduces the ability of the blood to coagulate, resulting in uncontrolled bleeding. A platelet count of \< 50 x 109 /L will be considered at high risk of increased bleeding.
- Severe extrahepatic complication (Hypoxemia, Acute renal failure…)
- Pregnant, diabetic patients
- Patients having an auto-immune disease
- Patients taking anticoagulant drugs or drugs that cause elevated liver enzymes (non-steroidal anti-inflammatory drugs, antibiotics, antiepileptic drugs, inhibitors of hydroxyl-methyl-glutaryl-coenzyme a reductase (statins), and anti-tuberculosis drugs) were excluded from the study
Key Trial Info
Start Date :
October 15 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 18 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03421990
Start Date
October 15 2017
End Date
January 18 2018
Last Update
March 21 2018
Active Locations (2)
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1
Ahmed Abdalla Mohamed
Cairo, Egypt, 11451
2
Ahmed Abdalla
Cairo, Egypt, 11451