Status:
COMPLETED
Energy Expenditure and Weight Loss Maintenance
Lead Sponsor:
University of Colorado, Denver
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Obesity
Weight Change, Body
Eligibility:
All Genders
18-65 years
Brief Summary
Obesity is reaching epidemic proportions and threatens both health and quality of life of people around the world. While many individuals succeed at short term weight loss, weight loss maintenance is ...
Detailed Description
Participants were recruited in three groups: weight loss maintainers (WLM: maintaining ≥13.6 kg weight loss for ≥1 year), normal weight controls (NC: Body Mass Index (BMI) matched to current BMI of WL...
Eligibility Criteria
Inclusion
- Men or women
- Age 18-65
- Weight stable (\<10 lb fluctuation in body weight over previous 6 months) or
- NWCR subjects successful at weight loss maintenance (maintaining a loss of ≥ 30 pounds for at least 2 years)
- Non-Reduced Weight Matched Controls: Individuals matched to NWCR subjects' current body weight. These individuals will be normal weight (BMI 18-25, BMI up to 27 allowed in men with waist circumference \< 40 cm), and have no history of overweight or obesity (BMI \>25) and will not be maintaining a weight loss ≥ 30 pounds.
- Non-Reduced Obese Controls: Individuals matched to NWCR subjects' maximum pre-weight loss body weight. These individuals will be overweight or obese (BMI ≥ 26-45).
Exclusion
- Diabetes
- Uncontrolled HTN (\>160/100)
- History of cardiac disease: CHF or angina, atrial fibrillation or ventricular tachycardia, or significant abnormality on resting EKG
- Symptoms suggestive of cardiovascular disease: chest pain, shortness of breath at rest or with mild exertion, dizziness, syncope.
- History of neurological disease: stroke, TIA or seizure disorder
- Current treatment for cancer (except skin)
- Severe pulmonary, liver or kidney disease
- Untreated thyroid disorder
- Severe arthritis or other musculoskeletal disorder
- Alcohol or drug abuse
- Active psychiatric illness
- Positive response to PAR-Q indicating requirement for monitored physical activity
- Other serious medical condition as determined by the investigator which would limit physical activity or require monitored activity.
- Pregnant and lactating women, and women actively trying to become pregnant (post-menopausal women on a stable dose of HRT and pre-menopausal women on a stable OCP regimen will be allowed to participate)
- Smoking within the past 6 months
- Subjects using prescription or over the counter medication which may affect RMR including beta blockers, stimulants such as Ritalin and appetite suppressants.
- Subjects who have undergone bariatric surgery or who are currently maintaining their weight loss with prescription weight loss drugs or supplements.
- Severe claustrophobia
- Moderate or high levels of physical activity at the workplace and unable to reduce workplace activity, work from home or take time off from work to participate in Study 2.
- We will exclude controls if they are weight reduced (maintaining a weight loss of ≥ 30 pounds).
Key Trial Info
Start Date :
October 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT03422380
Start Date
October 1 2009
End Date
September 1 2012
Last Update
February 5 2018
Active Locations (1)
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1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045