Status:
RECRUITING
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma
Lead Sponsor:
Medical University of Vienna
Conditions:
Glaucoma
Eligibility:
All Genders
21-105 years
Brief Summary
There is increasing evidence that there are genetic risk factors for several forms of glaucoma, such as glaucoma caused by pseudoexfoliation syndrome (PXF) ,primary angle closure glaucoma (PACG) and p...
Detailed Description
As worldwide populations become older because of shifts in demography, PXF may become a matter of greater concern. The search for genes responsible for PXF may lead to the identification of key molecu...
Eligibility Criteria
Inclusion
- For patients with PXF:
- Patients with confirmed pseudoexfoliation syndrome (exfoliation glaucoma / pseudoexfoliation of the lens) in the medical history
- Informed consent
- Age 50 years or more
- For patients with PACG:
- Patients with confirmed acute primary angle closure (PAC) or primary angle closure glaucoma (PACG) in the medical history
- Informed consent
- Age 21 years or more
- For healthy controls:
- No evidence of PXF, glaucoma or uveitis during clinical examination or in the medical history
- No evidence of major ocular disease such as diabetic retinopathy, age related macular degeneration or conditions with genetic background during clinical examination or in the medical history
- Age more than 60 years
- Informed consent
- For patients with POAG:
- Patients with confirmed primary open angle glaucoma (POAG)
- No evidence of exfoliation glaucoma / pseudoexfoliation of the lens or pigment glaucoma
- Informed consent
- Age 30 or more
Exclusion
- Patients and subjects will be excluded if one or more of the following criteria apply:
- Neovascular glaucoma
- Active or history of uveitis
- Secondary angle closure such as neovascular glaucoma or uveitis/inflammatory eye disease
- Inability to give informed consent
Key Trial Info
Start Date :
May 30 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 30 2026
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT03423758
Start Date
May 30 2017
End Date
January 30 2026
Last Update
May 23 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Austria, 1090