Status:
ACTIVE_NOT_RECRUITING
An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia
Lead Sponsor:
BioMarin Pharmaceutical
Conditions:
Achondroplasia
Eligibility:
All Genders
6+ years
Phase:
PHASE3
Brief Summary
The intent and design of this Phase 3 study is to assess BMN 111 as a therapeutic option for the treatment of children with Achondroplasia
Eligibility Criteria
Inclusion
- Must have completed Study 111-301
- Female \>= 10 years old or who have begun menses must have a negative pregnancy test at the Baseline Visit and be willing to have additional pregnancy tests during the study
- If sexually active, willing to use a highly effective method of contraception while participating in the study
- Are willing and able to perform all study procedures
- Parent(s) or guardian(s) are willing and able to provide written, signed informed consent after the nature of the study has been explained and prior to performance of any research-related procedure. Also, subjects under the age of majority are willing and able to provide written assent (if required by local regulations or the IRB/IEC) after the nature of the study has been explained and prior to performance of any research-related procedure. Subjects who reach the age of majority in their country while the study is ongoing will be asked to provide their own written consent again upon reaching the legal age of majority.
Exclusion
- Permanently discontinued BMN 111 or placebo prior to completion of the 111-301 study
- Have a clinically significant finding or arrhythmia on Baseline ECG that indicates abnormal cardiac function
- Evidence of decreased growth velocity (\<1.5 cm/year) as assessed over a period of at least 6 months or of growth plate closure (proximal tibia, distal femur) through bilateral lower extremity X-rays.
- Require any investigational agent prior to completion of study period
- Current therapy with medications known to alter renal function
- Pregnant or breastfeeding or plan to become pregnant during study
- Concurrent disease or condition that, in the view of the investigator, would interfere with study participation or safety evaluations, for any reason.
- Have a condition or circumstance that, in the view of the investigator, places the subject at high risk for poor treatment compliance or for not completing the study.
Key Trial Info
Start Date :
December 12 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2031
Estimated Enrollment :
119 Patients enrolled
Trial Details
Trial ID
NCT03424018
Start Date
December 12 2017
End Date
June 1 2031
Last Update
January 9 2025
Active Locations (24)
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1
Children's Hospital & Research Center Oakland
Oakland, California, United States, 94609
2
Harbor - UCLA Medical Center
Torrance, California, United States, 90509
3
Alfred I. duPont Hospital for Children
Wilmington, Delaware, United States, 19803
4
Emory University
Atlanta, Georgia, United States, 30322