Status:
COMPLETED
Genetic Variation in Organic Cation Transport 1 (OCT1) and Its Significance for Morphine Pharmacokinetics
Lead Sponsor:
University of Southern Denmark
Collaborating Sponsors:
Danish Council for Independent Research
The Faculty of Health Sciences SDU
Conditions:
Organic Cation Transporter 1
Morphine
Eligibility:
All Genders
18-90 years
Phase:
PHASE1
Brief Summary
The main objective of the trial is to investigate the effect of known genetic variants in organic cation transporter 1 (OCT1) on the effect of morphine after major surgery
Detailed Description
The purpose of the experiment is to investigate the effect of known genetic variants in organic cation transporter 1 (OCT1) on the effect of morphine after major surgery. This is primarily done by inv...
Eligibility Criteria
Inclusion
- Planned Colectomy / Hemicolectomy, sigmoid resection, rectal resection or abdominal perianal amputation of the rectum with stoma, good general health (ASA 1 -2), Informed consent given, Age 18-90 years and BMI 18,5 - 35kg/m².
Exclusion
- Abdominoperineal resection (APR) - ad modum Holm (abdominal perianal amputation of rectum with stoma)
- Daily use of opioids
- Indicator for the use of an epidural catheter
- Alcohol abuse
- Hypersensitivity for morphine
- A known serious disease (Terminal cancer, severe dementia, significant heart, liver, lung or renal failure or severe psychiatric disease)
- Women of childbearing age who do not use safe contraception
- Women who are breastfeeding
- Pregnant women
Key Trial Info
Start Date :
June 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 7 2020
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT03425084
Start Date
June 1 2018
End Date
February 7 2020
Last Update
June 29 2020
Active Locations (2)
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1
Sydvestjysk Sygehus
Esbjerg, Denmark, 7100
2
Odense Universitetshospital
Odense, Denmark, 5000