Status:
UNKNOWN
Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder
Lead Sponsor:
University Hospital, Clermont-Ferrand
Collaborating Sponsors:
CH MONTLUCON
Jacques Lacarin Hospital Center
Conditions:
Narcolepsy
Cataplexy
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Up to 50% of Narcolepsy-cataplexy (NC) patients suffer from REM sleep behavior disorder (RBD), a parasomnia. A strong link was found between RBD and impulse control disorders (ICD) in Parkinson disea...
Detailed Description
Type of study: Prospective, case control study. Number of centers: 3 (Clermont-Ferrand, Vichy and Montlucon) Patients : The study will be performed in 66 subjects (22 PD patients with RBD, 22 PD pa...
Eligibility Criteria
Inclusion
- \- Men or women, right handed, 18 to 80 years
- Patients with type 1 Narcolepsy according to the criteria of the International Classification of Sleep, 3rd version, 2014
- Acceptance of the protocol and signature of a written consent
- Social security affiliation
Exclusion
- Previous history of psychosis or psychiatric disease
- History of stroke or vascular lesion on MRI.
- Perceptual disorder (vision, hearing) may hinder the realization of the protocols,
- Dementia defined by a score across Montreal Cognitive Assessment (MoCA) \<26/30.
- Major depressive state defined by a score scale Beck Depression Inventory (BDI)\> 14
- Apathy defined by a score ≥ 14 on the Apathy Scale of Starkstein. Patients with a score ≥ this one will be excluded.
- Usual contraindications to MRI, knowing that no contrast agent injection is performed.
- Pregnant woman.
Key Trial Info
Start Date :
January 19 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2019
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT03425214
Start Date
January 19 2018
End Date
June 30 2019
Last Update
February 9 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
CHU Clermont-Ferrand
Clermont-Ferrand, France, 63003