Status:
COMPLETED
Glutamate Supplementation in Young Men
Lead Sponsor:
University of Waterloo
Conditions:
Healthy
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
Amino acids play an important role in human metabolism. In aging individuals and in some diseases, certain amino acids, such as glutamate, are at lower than normal levels. Glutamate appears to be invo...
Detailed Description
Glutamate is involved in several aspects of glucose metabolism in both muscle and liver, however its role has not been fully defined. It is the primary amino acid taken up by resting and exercising sk...
Eligibility Criteria
Inclusion
- BMI in the normal or overweight range (18.5-30.0 kg/m2)
- Weight stable for the past 6 months
- Participate in aerobic and/or resistance-type exercise 3-5 times per week (no more then 2 hours per session and/or 5 sessions per week)
- Fasting blood glucose \< 6.0 mM
- Resting blood pressure \< 140/90 mmHg
- Answer "no" to all questions on the Get Active Questionnaire (GAQ)
Exclusion
- Smoking
- Known allergy or intolerance to MSG
- Diabetes, cancer, or other metabolic disorders
- Cardiac or gastrointestinal problems
- Infectious disease
- Injuries that prevent safe participation and exercise or instructions from healthcare provider to refrain from exercise
- Barium swallow or nuclear medicine scan in the previous 3 weeks
- If receiving a DXA scan will cause the participant to exceed the maximum trivial dose of radiation per year
- Prescription anti-coagulant or anti-platelet medication (e.g. warfarin, heparin, clopiodogrel)
Key Trial Info
Start Date :
March 19 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 2 2018
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT03425578
Start Date
March 19 2018
End Date
October 2 2018
Last Update
June 12 2019
Active Locations (1)
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1
University of Waterloo
Waterloo, Ontario, Canada, N2L 3G1