Status:
COMPLETED
Cardiovascular Status in Adrenal Insufficiency
Lead Sponsor:
Wuerzburg University Hospital
Conditions:
Adrenal Insufficiency
Eligibility:
All Genders
18+ years
Brief Summary
Within this trial, the cardiovascular status and metabolic profile of patients with chronic primary adrenal insufficiency is evaluated.
Detailed Description
An unfavorable metabolic profile in patients with adrenal insufficiency (AI) under hormone replacement therapy with hydrocortisone (HC) has been revealed in one recent analysis. Furthermore an increas...
Eligibility Criteria
Inclusion
- Chronic primary adrenal insufficiency
- Adequate hormone replacement therapy (\>3 years)
- Age \>18 years
- Patient's informed consent
Exclusion
- Hormone replacement therapy with an other glucocorticoid than hydrocortisone
- Pharmacotherapy with glucocorticoids
- Congenital adrenal hyperplasia
- Coronary heart disease
- Heart failure
- Systemic disease with (potential) cardiac involvement (e.g. amyloidosis, lung fibrosis)
- Pregnancy
- Chronic alcohol abuse
- Malignant disease
- Arterial hypertension
- Chronic renal failure (MDRD \<60)
Key Trial Info
Start Date :
August 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT03426319
Start Date
August 1 2013
End Date
June 1 2014
Last Update
February 8 2018
Active Locations (1)
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1
University Hospital Wuerzburg
Würzburg, Germany, 97080