Status:
COMPLETED
Multi-Center Evaluation of Feasibility of SPECT Measurement of Myocardial Blood Flow and Reserve
Lead Sponsor:
Ottawa Heart Institute Research Corporation
Collaborating Sponsors:
GE Healthcare
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Brief Summary
Patients will be recruited from those referred to the local site's Diagnostic Imaging Department for SPECT myocardial perfusion imaging (MPI) ,who have an intermediate to high pre-test likelihood of d...
Detailed Description
Patients will be recruited from those referred to the local site's Diagnostic Imaging Department for SPECT myocardial perfusion imaging (MPI), who have an intermediate to high pre-test likelihood of d...
Eligibility Criteria
Inclusion
- Age ≥ 18 years old
- BMI ≤ 40 kg/m2
- Able and willing to comply with the study procedures
- Written informed consent
- Intermediate to high probability of CAD
- Suspected or known CAD on a stable medication regime
Exclusion
- History or risk of severe bradycardia (heart rate \< 50 beats per minute) not related to chronotropic drugs
- Known second- or third-degree AV block without pacemaker
- Dyspnea (NYHA III/IV), wheezing asthma or COPD
- Coronary artery bypass graft (CABG) surgery within 60 days prior to screening or within 45 days after consent (early revascularization)
- Percutaneous coronary intervention (PCI) within 30 days prior to screening or within 45 days following consent (early revascularization)
- Recent use of dipyridamole, dipyridamole-containing medications (e.g. Aggrenox)
- Known hypersensitivity to dipyridamole or adenosine
- Breastfeeding or pregnancy
- Claustrophobia or inability to lie still in a supine position
- Unwillingness or inability to provide informed consent
Key Trial Info
Start Date :
October 12 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2022
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT03427749
Start Date
October 12 2018
End Date
October 1 2022
Last Update
April 10 2025
Active Locations (7)
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1
Universitaire ziekenhuizen Leuven
Leuven, Belgium
2
London Health Sciences Centre
London, Ontario, Canada
3
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
4
Medizinische Hochschule Hannover
Hanover, Germany