Status:
COMPLETED
Effect of Flavonoids on Gut Permeability in Cyclists
Lead Sponsor:
Utah State University
Conditions:
Gut Permeability, Gut Inflammation
Eligibility:
All Genders
18-49 years
Phase:
PHASE1
Brief Summary
The purpose of this investigation is to test the hypothesis that chronic supplementation with a dairy-based beverage containing a mixture of blueberry, green tea, and cocoa flavonoids (non-nutritive n...
Eligibility Criteria
Inclusion
- Male or female of any race or ethnicity between 18 to 49 years of age
- Competed in a road race or triathlon in past 12 months
- Free of chronic disease and GI conditions
- Train at least 3 times per week, 1 hour at a time on average
- Willing to prepare and consume provided pre-workout beverage daily
- Maintain weight (no more/less than 5 kg change)
- Willing to avoid consumption of high flavonoid foods/supplements, large dose vitamin and mineral supplements, and NSAIDs or other medications known to affect inflammation during study period
- Willing to provide urine, stool, and blood samples
Exclusion
- Age \<18 or \>50 years
- Medical history of heart disease, hypertension, diabetes, Crohn's disease, IBS, colitis, celiac disease, inflammatory or autoimmune disease, and lactose intolerance
- Uncontrolled hypertension: diastolic blood pressure \>95 mm Hg or systolic blood pressure \>160 mm Hg
- For women: pregnancy, breast feeding or postpartum \<6 months
- Food allergies or restrictions to treatment/placebo beverages
- Chronic use of NSAIDs
- Consumption of flavonoid supplements \<1 month prior to study start
- Antibiotic use \<3 months prior to study start
- Other conditions (medical, psychiatric, or behavioral) that may present a safety hazard to the participant or interfere with study participation, as determined by the principal investigators
Key Trial Info
Start Date :
September 14 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2019
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03427879
Start Date
September 14 2018
End Date
July 31 2019
Last Update
February 25 2021
Active Locations (1)
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1
Center for Human Nutrition Studies
Logan, Utah, United States, 84322