Status:
COMPLETED
Brain Networks and Mobility Function: B-NET
Lead Sponsor:
Wake Forest University Health Sciences
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Central Nervous System
White Matter Disease
Eligibility:
All Genders
70+ years
Brief Summary
Rapidly accumulating evidence indicates that the central nervous system (CNS) plays a pivotal role in mobility function with age-associated CNS changes strongly contributing to declining mobility. Stu...
Detailed Description
Studies linking the brain to mobility have used anatomical measures like brain volume and white matter integrity, and suggest that damage to the connecting fibers of the brain (white matter) is relate...
Eligibility Criteria
Inclusion
- Community-dwelling adults aged ≥70 years
- Willing to provide informed consent; ability to communicate with study personnel.
Exclusion
- Serious or uncontrolled chronic disease such as:
- Cancer (stage 3 or 4) or having had radiation or chemotherapy in the past year
- Uncontrolled angina
- Heart failure (stage 3-4)
- Respiratory disease requiring the use of oxygen
- Uncontrolled endocrine/metabolic disease (fasting glucose \>250mg/dL)
- Liver failure (AST \> 40IU/L and/or ALT \> 44 IU/L)
- Renal failure requiring dialysis
- Clinically diagnosed neurologic diseases: Parkinson's disease; Amyotrophic Lateral Sclerosis (ALS); Multiple Sclerosis, prior stroke with residual effects lasting longer than 24hrs
- Diagnosis of schizophrenia, bipolar, or other psychotic disorder
- Diagnosis of Alzheimer's disease or evidence of impaired cognitive function
- Prior traumatic brain injury with residual deficits
- Unwilling or unable to have an MRI brain scan (see MRI screening form).
- Dependent on a walker or another person to ambulate.
- Plans to relocate in the next 2- 3 years.
- Single or double amputee
- Musculoskeletal impairments severe enough to preclude functional testing
- Participating in an exercise or cognitive enhancing intervention
- Any other reason the PI or study physician feels the participant would not adhere to the protocol
Key Trial Info
Start Date :
July 20 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 12 2023
Estimated Enrollment :
192 Patients enrolled
Trial Details
Trial ID
NCT03430427
Start Date
July 20 2018
End Date
July 12 2023
Last Update
August 18 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States, 27157