Status:
COMPLETED
Is Tau Protein Linked to Mobility Function?
Lead Sponsor:
Wake Forest University Health Sciences
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Alzheimer Disease
Physical Activity
Eligibility:
All Genders
50+ years
Brief Summary
This project will provide new data to address an important question linking Alzheimer's disease neuropathology to physical disability.
Detailed Description
Impaired mobility is strongly linked to cognitive function and vice versa. Cognitive functions are strongly associated with mobility function, most commonly assessed using gait speed. In the Health AB...
Eligibility Criteria
Inclusion
- 50+ years of age and participated in the Wake Forest Alzheimer's Disease Core Center study
- Willing to provide informed consent
- Not dependent on a walker
Exclusion
- Recent cardiac event in the last 6 months
- Uncontrolled hypertension (BP \>200/110 mmHg)
- Neurological (e.g., Parkinson's) or hematological disease
- Participants with a knee replacement in last 6 months
- Participants with recent eye surgery in last 6 months
- Severe musculoskeletal impairment (e.g., sciatica, fibromyalgia, severe leg/back pain)
- If willing to get an MRI, must not have indwelling metal-contraining prosthesis, pacemaker or defibrillator, history of welding, permanent make up or head/neck tattoo, or any other contraindication to MRI
Key Trial Info
Start Date :
September 7 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 27 2021
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT03430648
Start Date
September 7 2017
End Date
September 27 2021
Last Update
August 31 2023
Active Locations (1)
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1
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States, 27157