Status:
COMPLETED
The Effect of Losartan on Emotional Processing in Healthy Volunteers
Lead Sponsor:
University of Oxford
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
This experimental medicine study explores whether a single dose of losartan (50mg) versus placebo affects the processing of positive and negative stimuli, using fMRI.
Detailed Description
Losartan has been shown to accelerate fear extinction in animals and to prevent the development of anxiety disorders in humans, emphasising its potential to possibly enhance exposure therapy in humans...
Eligibility Criteria
Inclusion
- willing and able to provide informed consent
- male or Female, aged 18-50
- body mass index (BMI) of 18-30 kg/m2
- fluent English skills
- non- or light-smoker (\< 5 cigarettes a day)
Exclusion
- Female participant who is pregnant or breast-feeding
- central nervous system (CNS) active medication during the last 6 weeks
- Current blood pressure/other heart medication (esp. aliskiren or beta blockers)
- Intravascular fluid depletion
- Past or present DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) axis-I diagnosis
- Alcohol or substance abuse
- First-degree family member with a history of a severe psychiatric disease
- Impaired liver or kidney function
- Lifetime history of epilepsy or other neurological disease, systemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.
- Insufficient English skills
- participated in another study involving certain medication during last 6 weeks
- Contraindication to magnet resonance imaging (MRI) scanning (e.g. pacemaker)
Key Trial Info
Start Date :
June 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2017
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03434054
Start Date
June 1 2016
End Date
June 30 2017
Last Update
February 19 2018
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