Status:
WITHDRAWN
Modulation of the Parieto-frontal Communication
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Normal Physiology
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
Background: Research shows that the parietal and prefrontal areas of the brain are involved in short-term memory. Researchers want to look at the effects of transcranial magnetic stimulation (TMS) of...
Detailed Description
Objective: This study aims to identify whether repetitive dual-site transcranial magnetic stimulation (TMS) can modulate the functional connectivity between the parietal and dorso-lateral prefrontal c...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age between 18-50 years.
- Right-handed (handedness questionnaire will be part of the initial evaluation)
- Able to give informed consent.
- Have a normal neurological exam within the last year and MoCA\>27
- Willing and able to abstain from alcohol for at least 48 hours prior to the study.
- Willing to not participate in other rTMS studies in the week preceding visits for the current protocol.
- EXCLUSION CRITERIA:
- All participants must be able to undergo MRI and TMS, for which the MRI- and TMS-safety checklists will be part of the initial evaluation, and reconfirmed at the beginning of every visit. It will constitute as exclusion criteria if the participant:
- has metal in his/her body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, or if he/she was a welder or metal worker, since small metal fragments may be found in the eyes.
- is uncomfortable in small closed spaces (claustrophobia) so that he/she would feel uncomfortable in the MRI machine.
- is not able to lie comfortably on the back for up to 2 hours
- has hearing loss.
- -is pregnant.
- Self-reported consumption of \>14 alcoholic drinks/week for a man and \>7 alcoholic drinks/week for a woman.
- History of or current brain tumor, stroke, head trauma with loss of consciousness, epilepsy or seizures.
- Taking medications that act directly on the central nervous system such as anti-epileptics, anti-histamines, anti-parkinsonian medication, medication for insomnia, anti-depressants, anti-anxiety medication.
Exclusion
Key Trial Info
Start Date :
February 3 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 25 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03434093
Start Date
February 3 2019
End Date
February 25 2019
Last Update
February 28 2019
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