Status:
UNKNOWN
The Effects of Lipinova on Inflammatory and Proresolving Lipid Mediator Profiles After Orthopedic Surgery
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Inflammation
Surgery
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
The aim of this pilot study is to investigate whether pre-operative supplementation with an over the counter dietary supplement containing a fractionated marine lipid concentrate derived from anchovy ...
Detailed Description
The resolution of acute inflammation was once thought to be a passive process, meaning that inflammatory mediators from the acute response (e.g. chemoattractants, complement components, prostaglandins...
Eligibility Criteria
Inclusion
- Patients scheduled to undergo total knee arthroplasty at Brigham and Women's Hospital
Exclusion
- current treatment with corticosteroids or NSAIDs
- evidence of active infection
- chronic liver disease
- end stage renal disease (CKD-5)
- chronic inflammatory disorders
- recent major illness or surgery within 30 days
- use of immunosuppressive medication
- history of organ transplantation
- pregnancy or plans to become pregnant, or lactating
- allergies to fish or fish oil
- coagulation disorders or thrombocytopenia (platelet \< 150,000)
Key Trial Info
Start Date :
March 15 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2018
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03434236
Start Date
March 15 2018
End Date
November 1 2018
Last Update
February 15 2018
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