Status:
COMPLETED
Prasugrel vs. Ticagrelor on Myocardial Injury in STEMI
Lead Sponsor:
AORTICA Group
Conditions:
ST Elevation Myocardial Infarction
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The investigators propose to perform a randomized clinical trial comparing prasugrel vs. ticagrelor in 60 patients with ST elevation acute myocardial infarction (STEMI) undergoing primary percutaneous...
Detailed Description
Dual antiplatelet therapy consisting of aspirin and one of the P2Y12 receptor inhibitors is the mainstay of treatment for patients with ST elevation acute myocardial infarction undergoing primary perc...
Eligibility Criteria
Inclusion
- age 18 years or older and equal or less than 75 years
- symptom onset within 12 hours before random assignment
- chest pain lasting more than 30 minutes
- ST-segment elevation of at least 0.1 mV in at least 2 limb leads, ST-segment elevation of at least 0.2 mV in 2 or more contiguous precordial leads, or left bundle-branch block or paced rhythm
- time from symptoms onset to randomization less than 6 hours
- no severe heart failure (Killip class \<3)
- informed, written consent
Exclusion
- history of myocardial infarction with Q wave
- history of surgical or percutaneous coronary revascularization
- cardiogenic shock, defined as a systolic blood pressure \<90 mm Hg with no response to fluid administration or \<100 mm Hg in patients with supportive treatment and no bradycardia
- history of stroke
- history of bronchial asthma
- symtomatic sinusal bradicardia or advance AV block
- history of hypersensitivity to aspirin, prasugrel or ticagrelor or contraindication to the doses established in the study
- patients pretreated with 600 mg of clopidogrel or more
- contraindication for the use of gadolinium during the magenitc resonance
Key Trial Info
Start Date :
November 23 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2018
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT03435133
Start Date
November 23 2015
End Date
December 31 2018
Last Update
June 10 2019
Active Locations (1)
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1
Pedro Dorado
Salamanca, Spain, 37007