Status:
COMPLETED
OxSYPan: Oxford Study With Young People on Antidepressants
Lead Sponsor:
University of Oxford
Conditions:
Depression
Eligibility:
All Genders
13-18 years
Phase:
NA
Brief Summary
Fluoxetine is commonly used to treat adolescent depression, but the neural mechanisms underlying antidepressant drugs in the young brain are still poorly understood. This study proposes to investigate...
Detailed Description
Depression is common in adolescence and is associated with a high risk of suicide. Clinically, the presentation of depression in young people is largely similar to the symptoms seen in adulthood, alth...
Eligibility Criteria
Inclusion
- Current episode of depression with or without comorbid anxiety and in need of antidepressant medication (as assessed by the Adolescent Psychiatrist);
- Participant and parent/legal guardian (for participants younger than 16) are willing and able to give informed consent for participation in the study;
- Male or female, aged 13-18;
- Sufficiently fluent in English to understand the task and instructions.
Exclusion
- Current or past psychosis or mania;
- Current substance misuse;
- Psychotropic medication usage within the past 6 weeks;
- Contraindication to fMRI (e.g. metal in body, claustrophobia, pregnancy, etc);
- Risk of waiting 5-7 days before the initiation of medication assessed as posing serious risk (as assessed by the Adolescent Psychiatrist).
Key Trial Info
Start Date :
May 23 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 10 2015
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT03436173
Start Date
May 23 2012
End Date
November 10 2015
Last Update
February 20 2018
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