Status:
COMPLETED
Dexmedetomidine and 5-year Outcome in Elderly Patients After Surgery
Lead Sponsor:
Peking University First Hospital
Collaborating Sponsors:
Peking University Third Hospital
Conditions:
Aged
Operative
Eligibility:
All Genders
65-90 years
Phase:
NA
Brief Summary
Delirium is a frequent postoperative complication. Its occurrence is associated with worse long-term outcomes. In a previous randomized controlled trial, prophylactic low-dose dexmedetomidine infusion...
Detailed Description
Delirium is a frequent postoperative complication; a systematic review revealed that postoperative delirium occurs in 36.8% of surgical patients, and its prevalence increases with age. The occurrence ...
Eligibility Criteria
Inclusion
- Patients were included if they met all of the following criteria:
- Age of 65 years or older;
- Underwent elective noncardiac surgery under general anesthesia;
- Admitted to ICU after surgery.
Exclusion
- Patients were excluded if they met any of the following criteria:
- Preoperative history of schizophrenia, epilepsy, Parkinsonism or myasthenia gravis;
- Inability to communicate in the preoperative period (because of coma, profound dementia or language barrier);
- Brain injury or neurosurgery;
- Preoperative left ventricular ejection fraction \< 30%, sick sinus syndrome, severe sinus bradycardia (\< 50 beats per minute), or second-degree or greater atrioventricular block without pacemaker;
- Serious hepatic dysfunction (Child-Pugh class C);
- Serious renal dysfunction (undergoing dialysis before surgery); or
- Unlikely to survive for more than 24 hours.
Key Trial Info
Start Date :
June 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2019
Estimated Enrollment :
700 Patients enrolled
Trial Details
Trial ID
NCT03436472
Start Date
June 1 2017
End Date
April 1 2019
Last Update
June 21 2019
Active Locations (1)
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1
Peking University First Hospital
Beijing, China, 100034