Status:
COMPLETED
Assessment of Portal Hypertension With Multiparametric MRI
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Portal Hypertension
Clinically Significant Portal Hypertension
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine whether new multiparametric magnetic resonance imaging (MRI) methods (including diffusion-weighted MRI, dynamic contrast-enhanced MRI, MR elastography and pha...
Detailed Description
Liver cirrhosis has been historically classified as a single histopathologic entity, as it is considered to be the latest fibrosis stage; however it is well known that cirrhosis encompasses different ...
Eligibility Criteria
Inclusion
- Chronic liver disease (including all etiologies of liver disease)
- 18 years of age and older
- Patient is able to give informed consent for this study
- Patients preferably (but not necessarily) underwent/will undergo:
- Liver biopsy (percutaneous or transjugular or surgical) performed within 6 months, as part of routine clinical care and/or HVPG measurement as part of their clinical care (within 6 months) and/or clinically indicated upper gastrointestinal endoscopy.
- and/or
- Liver transplant or liver resection performed as part of routine clinical care and/or
- Medical therapy for portal hypertension or TIPS placement as part of routine clinical care.
- Control group
- Healthy volunteers without history of liver disease (will be used for the purpose of image optimization). These subjects will NOT undergo HVPG measurement.
- 18 years of age and older
Exclusion
- Age less than 18 years
- Unable or unwilling to give informed consent
- Contra-indications to MRI
- Electrical implants such as cardiac pacemakers or perfusion pumps
- Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants
- Ferromagnetic objects such as jewelry or metal clips in clothing
- Pregnant subjects
- Pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions.
Key Trial Info
Start Date :
March 20 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 19 2022
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT03436550
Start Date
March 20 2018
End Date
July 19 2022
Last Update
March 6 2023
Active Locations (1)
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1
Mount Sinai Medical Center
New York, New York, United States, 10029