Status:
UNKNOWN
Antibiotic Prophylaxis in Rectal Cancer Surgery: Oral With Intravenous Versus Intravenous Antibiotics.
Lead Sponsor:
State Scientific Centre of Coloproctology, Russian Federation
Conditions:
Rectal Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a randomized, controlled, parallel study to determine the efficiency of oral antibiotics in reduction of surgical site infection (SSI) in rectal cancer surgery.
Detailed Description
Patients undergoing rectal cancer surgery in a single centre will assigned randomly to combined preoperative oral antibiotics (metronidazole and erythromycin) and perioperative intravenous antibiotics...
Eligibility Criteria
Inclusion
- Have a planned of resection of rectum
- Have signed approved informed consent form for the study.
Exclusion
- Significant simultaneous surgical procedure (e.g., liver resection of metastasis)
- Bacterial infection at the time of surgery or antimicrobial therapy up to 4 weeks before surgery
- Preoperative severe impairment in renal function (creatinine clearance (MDRD) \< 30 ml/min)
- Allergy on the study drugs .
Key Trial Info
Start Date :
November 6 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2020
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT03436719
Start Date
November 6 2017
End Date
August 31 2020
Last Update
March 5 2019
Active Locations (1)
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1
State Scientific Centre of Coloproctology
Moscow, Russia, 123423