Status:
COMPLETED
Genomic Determinants and Shared Genetic Pathways of Periodontal Disease
Lead Sponsor:
Tufts University
Collaborating Sponsors:
Brigham and Women's Hospital
National Institute of Dental and Craniofacial Research (NIDCR)
Conditions:
Periodontal Diseases
Diabetes
Eligibility:
FEMALE
45-100 years
Brief Summary
Despite significant improvement in treating periodontal disease (PD) and the identification of multiple risk factors, little is known about the specific contribution of genetics to PD pathogenesis. Se...
Detailed Description
Three specific aims are proposed to refine and validate the PD status in the Women's Health Study (WHS/WGHS) to improve the phenotypic characterization of GWAS of PD: (1) Addition of CDC-AAP (Centers ...
Eligibility Criteria
Inclusion
- Women who are willing to consent for requesting dental records;
- Outcome 1 - Women who reported periodontal disease diagnosis at any time point up to the 2006 follow up;
- Outcome 1 - Women whose dental records will be retrievable and usable (retrospectively 2 years and prospectively 1 year at the time of report of periodontal disease diagnosis)
- Outcome 2 - Women who are willing to complete and turn-in the WHS 2018 Annual Follow-up Questionnaire with CDC-AAP oral health questions
- Outcome 2 - Women whose dental records will be retrievable and usable (retrospectively 3 years at the time of 2018 Annual Follow-up Questionnaire turn-in)
- The definition of usable dental records consist of but not exclusive to clinical note, complete periodontal charting, and full-mouth radiographs series (FMX) or panoramic, bite-wing radiographs that could derive a PD diagnosis based on the American Academy of Periodontology 1999 definitions.
Exclusion
- \- Women whose dental records are not retrievable or incomplete.
Key Trial Info
Start Date :
January 30 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2023
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT03437798
Start Date
January 30 2018
End Date
December 31 2023
Last Update
April 11 2024
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215