Status:
COMPLETED
Lumbar Spine Muscle Degeneration Inhibits Rehabilitation-Induced Muscle Recovery
Lead Sponsor:
University of California, San Diego
Collaborating Sponsors:
Balgrist University Hospital
Spine Institute of San Diego (Spine Zone)
Conditions:
Disc Degeneration
Low Back Pain
Eligibility:
All Genders
21-85 years
Phase:
NA
Brief Summary
Low back pain (LBP) is a complex condition that affects 65-85% of the population, and is the leading musculoskeletal condition contributing to disability in the United States. Disc herniation is the m...
Detailed Description
AIM: To determine the effect of exercise on induction of muscle hypertrophic, fibrotic, inflammatory, and adipogenic pathways in patients with mild versus severe fatty infiltration of the multifidus m...
Eligibility Criteria
Inclusion
- Spine pathologies requiring un-instrumented surgery (i.e. laminectomy, laminoforaminotomy, or discectomy).
- Age 21-85 years of age.
Exclusion
- History of lumbar spine surgery.
- Patients requiring placement of instrumentation as part of the surgical procedure (i.e. fusion).
- Diabetes.
- Neuromuscular diseases.
Key Trial Info
Start Date :
July 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2023
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT03442374
Start Date
July 1 2019
End Date
October 1 2023
Last Update
November 28 2023
Active Locations (1)
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1
UC San Diego
La Jolla, California, United States, 92093