Status:
COMPLETED
Glucagon-like Peptide-2 Mediated Secretion of Stored Enteral Lipids
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Kensington Screening Clinic
Conditions:
Hyperlipidemias
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
PHASE3
Brief Summary
Some of the fat (triglyceride) from the food humans eat gets stored in the bowel. This triglyceride can then be released into the blood when another meal is consumed or in response to hormones. How th...
Detailed Description
The release of stored enteral lipids will be investigated in 30 patients undergoing upper gastrointestinal endoscopy and duodenal biopsy for clinical indications. Patients undergoing the procedure wil...
Eligibility Criteria
Inclusion
- Men and women, aged 18 to 60 years requiring endoscopy and duodenal biopsies for clinical indications, with no contraindications to the procedure, as judged by Dr. Bookman of the Kensington Screening Clinic, Toronto, ON, Canada
Exclusion
- Patients with active inflammatory bowel disease
- Patients with pre-existing Celiac disease, exocrine pancreatic insufficiency or small bowel malabsorption
- Patients with active bowel malignancy
- Patients with diabetes mellitus or known/ suspected motility disorders of the gut
- Patients with decompensated liver disease
- Patients on ezetimibe or bile acid sequestrants
- Patients who are pregnant or breastfeeding.
- Patients with renal disease
- Patients on benzodiazepine
- Unstable cardiac or respiratory disease
- Any changes to medication in the preceding month
Key Trial Info
Start Date :
January 17 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2021
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT03442972
Start Date
January 17 2019
End Date
December 1 2021
Last Update
May 25 2022
Active Locations (2)
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1
Toronto General Hopital
Toronto, Ontario, Canada, M5G 2C4
2
Kensington Screening Clinic
Toronto, Ontario, Canada, M5T 3A9