Status:
COMPLETED
Differential Metabolic Signature of Stroke Patients Undergoing Thrombolysis
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust
Conditions:
Stroke, Ischemic
Eligibility:
All Genders
18+ years
Brief Summary
Currently, there is no reliable biomarker for stroke, meaning that treatment is often delayed and patients are often left with a disability. Stroke is one of the largest causes of mortality (death) an...
Detailed Description
There are around 150,000 incidents of stroke every year in the UK alone. By the age of 75, 1 in 5 women and 1 in 6 men will have had a stroke; 26% of which will have occurred before the age of 65. Mor...
Eligibility Criteria
Inclusion
- Inclusion Criteria (stroke patients):
- Be aged 18 years or over
- Present at Addenbrooke's Hospital A\&E with a stroke (ischaemic stroke)
- Time of onset of confirmed stroke symptoms within 4 hours of arrival in ED
- Be eligible for thrombolysis
- Provide informed consent either prior to thrombolysis or after the initial emergency; or personal or nominated consultee declaration following the emergency
- Inclusion Criteria (healthy volunteers):
- Be aged 18 years or over
- Provide informed consent
- Be healthy as determined by clinical history and examination by the investigator, a brief physical examination must be unremarkable.
- Exclusion Criteria (stroke patients):
- Patients qualifying for thrombolysis but who do not give consent
- Patients under the age of 18
- Patients who are currently actively involved with another clinical trial (including observational studies)
- Exclusion Criteria (healthy volunteers):
- Unable to provide informed written consent
- Participants under the age of 18
- Participants who are currently actively involved with another clinical trial (including observational studies)
- Any medical history or clinically relevant abnormality (from medical notes) that is deemed by the principal investigator and/or suitably qualified delegate to make the subject ineligible for inclusion
Exclusion
Key Trial Info
Start Date :
July 3 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 8 2021
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT03443245
Start Date
July 3 2019
End Date
August 8 2021
Last Update
February 8 2023
Active Locations (1)
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1
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom