Status:
COMPLETED
Impact of Short-term Fructose-enriched Diet on Serum Metabolome by Normal- and Over-weighed Women.
Lead Sponsor:
University of Hohenheim
Conditions:
Non-Alcoholic Fatty Liver Disease
Obesity
Eligibility:
FEMALE
20-30 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to investigate how a high-fructose diet, either by high fructose intake from complex, natural foods or by fortifying the diet with corn syrup, affects the metabolism. Furt...
Eligibility Criteria
Inclusion
- Healthy adults, aged between 20 and 30 years
- normal weighted (BMI ≤ 25 kg/m2) and obese (BMI 35-50 kg/m2)
- written informed consent
- At initial medical examination an anamnesis, physical examination, blood sample collection (10 ml) was performed to check for eligibility. Furthermore, a hydrogen breath test was performed to detect potential fructose intolerance
Exclusion
- smoking,
- fructose intolerance/ -malabsorption,
- pregnancy
- chronic gastrointestinal diseases (e.g. chronic inflammatory bowel disease, irritable bowel syndrome, celiac disease etc.),
- operation on the gastrointestinal tract (exclusively appendectomy)
- anemia,
- hepatic or renal disease
- diabetes mellitus
- consuming illnesses (e.g. cancer, acquired immunodeficiency syndrome (AIDS)) - drug intake affecting lipid or glucose metabolism (cholesterol- or glucose reducing or antihypertensive drugs, steroids, L-Thyroxin, antidepressants, weight reducing drugs).
Key Trial Info
Start Date :
August 15 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 15 2009
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03444233
Start Date
August 15 2009
End Date
October 15 2009
Last Update
February 23 2018
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