Status:
COMPLETED
The Relationship Between Arterial Stiffness and Respiratory Failure in Motor Neurone Disease
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Conditions:
Motor Neurone Disease
Hypoxemia and/or Hypercapnia
Eligibility:
All Genders
18-80 years
Brief Summary
* Patients with Motor Neurone Disease (MND) admitted to Lane Fox Unit /Royal Brompton Hospital and/or reviewed in Lane Fox Unit /Royal Brompton Hospital clinics and/or outreach review will be approach...
Detailed Description
The stiffness of the arterial wall is highly relevant to cardiovascular disease. Large elastic arteries and smaller muscular conduit arteries become stiffer with ageing, a process that is accelerated ...
Eligibility Criteria
Inclusion
- MND diagnosis
- The ability to perform the respiratory function testing satisfactorily
- Stable clinical and functional state for at least four weeks before testing
- BMI 20-30 kg•m-2
Exclusion
- Pregnancy
- Aged \<18, \>80
- Significant physical or psychiatric comorbidity that would prevent compliance with trial protocol
- Unstable clinical state
- Use of mechanical ventilation
- Cardiovascular disorders (history, physical examination)
- Known lung disease, such as asthma or COPD or any other cause of hypoxemia and/or hypercapnia but MND (history, physical examination, CXR review \[High Resolution Computed Tomography if CXR is not compatible with neuromuscular disease alone\])
- Airway obstruction (FEV1/FVC\<0.75)
- Diabetes mellitus
- Obesity (BMI\>30 kg•m-2)
- Smoking history (\>10 pack∙years or active smoker)
Key Trial Info
Start Date :
February 21 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2021
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT03444428
Start Date
February 21 2017
End Date
June 30 2021
Last Update
October 1 2021
Active Locations (2)
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1
Guys and St Thomas NHS Trust
London, United Kingdom, SE1 7EH
2
Royal Brompton and Harefield NHS Trust
London, United Kingdom, SW3 6NP