Status:
UNKNOWN
Assessment of Tidal Volume During Non Invasive Oxygenation Techniques
Lead Sponsor:
Henri Mondor University Hospital
Conditions:
Respiratory Failure With Hypoxia
Eligibility:
All Genders
18+ years
Brief Summary
High Tidal volume is one of the main mechanisms that lead to lung injuries under mechanical ventilation (ventilator induced lung injury: VILI). It could also induce lung damage during spontaneous or a...
Detailed Description
Background : De novo acute respiratory failure with moderate to severe hypoxemia is associated with high intubation and mortality rates. Under non-invasive ventilation (NIV) with a bucco-nasal mask, a...
Eligibility Criteria
Inclusion
- Respiratory rate \> 25 per minute
- PaO2/FiO2 \< 200 mmHg
- PaCO2 \< 45 mmHg
- Signed consent by patient or relative
Exclusion
- Chronic respiratory disease
- COPD exacerbation
- Acute asthma
- Cardiogenic pulmonary edema
- Hemodynamic instability (systolic blood pressure \< 90 mmHg or mean blood pressure \< 65 mmHg or use of catecholamines)
- Coma (Glasgow coma scale \< 12)
- Contraindication to non-invasive ventilation
- Indication to immediate intubation according to the physician
Key Trial Info
Start Date :
March 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2019
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT03445455
Start Date
March 1 2018
End Date
September 1 2019
Last Update
March 2 2018
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