Status:
UNKNOWN
Incidence of Dyssynchronies in Early ARDS
Lead Sponsor:
Unity Health Toronto
Conditions:
ARDS
Acute Hypoxemic Respiratory Failure
Eligibility:
All Genders
18+ years
Brief Summary
Patients sedated under mechanical ventilation with acute hypoxemic respiratory failure with a PaO2/FiO2 equal or less than 200mmHg (Acute Respiratory Distress Syndrome, ARDS and non-ARDS) will be incl...
Detailed Description
Measurements Physiological measurements Airway pressure, esophageal pressure, electrical activity of the diaphragm and flow 1. Flow and airway pressure signal will be recorded from the ventilators b...
Eligibility Criteria
Inclusion
- Moderate and severe ARDS and AHRF, according to the Berlin definition. The absence of the Chest X-Ray criterion (e.g. unilateral disease) or the presence of primary cardiac dysfunction will define AHRF.
- Continuous intravenous sedation
- Deep sedation: Richmond Agitation Sedation Scale (RASS) ≤ -3 or Riker Sedation-Agitation Scale (SAS) ≤ 3
Exclusion
- \<18 years
- Patients with a significant bronchopleural fistula
- Pure COPD exacerbation
- Patients on chronic home ventilation
Key Trial Info
Start Date :
January 15 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2022
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT03447288
Start Date
January 15 2017
End Date
August 1 2022
Last Update
September 30 2021
Active Locations (14)
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1
St Michael's hospital
Toronto, Ontario, Canada, M5B 1W8
2
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
3
Beijing Tiantan Hospital, Capital Medical University
Beijing, China, 100050
4
Centre Hospitalier Universitaire - CHU Angers
Angers, France, 49933