Status:
COMPLETED
[C-11]NOP-1A and Alcohol Use Disorder
Lead Sponsor:
Rajesh Narendran
Collaborating Sponsors:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Conditions:
Alcohol Use Disorder
Eligibility:
All Genders
18-55 years
Phase:
EARLY_PHASE1
Brief Summary
The goal of this study is to compare \[C-11\]NOP-1A binding in recently abstinent alcohol use disorders and controls
Detailed Description
This will allow for understanding brain stress and antistress mechanisms that underlie abuse of alcohol in humans
Eligibility Criteria
Inclusion
- \[A\] Alcohol use disorders (AUD)
- Males or Females
- Fulfill DSM5 diagnosis for alcohol use disorder
- Medically Healthy
Exclusion
- Pregnancy or lactation
- Comorbid severe/major medical, psychiatric (such as bipolar and psychotic disorders, etc.,) and current comorbid drug use disorders (other than tobacco use and recreational marijuana use)
- Metal implants or paramagnetic objects contained within the body which may interfere with MRI scans
- Currently employed as a radiation worker, or participation in radiation drug research procedures within the previous year
- Currently on any psychotropic medications that can influence nociceptin transmission in the brain
- \[B\]Healthy controls
- Inclusion Criteria:
- Males or females
- Absence of present or past psychiatric conditions (including alcohol or drug use disorders)
- Medically Healthy
Key Trial Info
Start Date :
May 27 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2021
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT03448016
Start Date
May 27 2016
End Date
March 30 2021
Last Update
July 11 2022
Active Locations (1)
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1
University of PIttsburgh PET Facility
Pittsburgh, Pennsylvania, United States, 15213