Status:
TERMINATED
Effect of Metformin on Frailty in 12 Subjects
Lead Sponsor:
Mayo Clinic
Conditions:
Aging
Inflammation
Eligibility:
All Genders
60+ years
Phase:
PHASE2
Brief Summary
This study will test whether chronic metformin administration will improve longevity of the cell, improves its machinery by reducing aging-related biochemical parameters and thereby improving physical...
Detailed Description
Heart disease is the number one cause of death in the United States and disproportionately affects older adults, underscoring the need to examine determinants of survivorship. Recognizing this gap, cu...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age ≥ 60 years
- Stable CAD
- Prediabetes (one of the following criteria should be met)
- Fasting plasma glucose: 100-126 mg/dL
- HbA1C: 5.7-6.4
- Frailty (Short Physical Performance Battery: Score \<9)
- Able to return for follow-up
- Written informed consent
- Exclusion criteria:
- Pre-existing or new-onset diabetes
- Any active malignancy, hematological disorder, post organ transplant, immunocompromised
- Cancer requiring treatment in the past 3 years (other than non-melanoma skin cancer)
- Dementia \[mini mental state examination (MMSE \<20)\]
- Disability (need for assistance in \>2 of any six activities on Katz activities of daily living (ADL)46
- Prior stroke with disability
- Acute coronary syndrome \<3months or participating in cardiac rehabilitation
- Severe Parkinson's
- Hepatic insufficiency and/or chronic liver disease (cirrhosis)
- Chronic kidney disease (GFR \< 45 mL/min)
- Taking metformin for any indication
- Acute alcohol intoxication
- Known hypersensitivity to metformin hydrochloride
- Acute/chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
Exclusion
Key Trial Info
Start Date :
May 24 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 16 2021
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT03451006
Start Date
May 24 2018
End Date
December 16 2021
Last Update
November 17 2022
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905