Status:
COMPLETED
Neurobiology of Sensory Phenomena in Obsessive-Compulsive Disorder
Lead Sponsor:
NYU Langone Health
Conditions:
Obsessive Compulsive Disorder
Eligibility:
All Genders
18-60 years
Brief Summary
The Research Domain Criteria (RDoC) approach seeks to address the neurobiological mechanisms of sensory symptoms in patients with obsessive-compulsive disorder (OCD) by investigating dimensional compo...
Detailed Description
This project investigates the neurobiological mechanisms of sensory symptoms in patients with obsessive-compulsive disorder (OCD) and their siblings using task-based fMRI, resting-state functional con...
Eligibility Criteria
Inclusion
- Fluent (speaking and writing) in English
- Additional criteria for healthy controls (HC):
- Lifetime absence of major Axis I diagnosis according to Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria
- Not taking psychotropic medications
- No first-degree biological relatives with OCD
- Additional criteria for siblings (SIB):
- First-degree biological sibling of a person with OCD
- Additional criteria for OCD patients:
- Diagnosis of OCD according to DSM-5 criteria.
Exclusion
- Current moderate or high suicidality as assessed through the Mini International Neuropsychiatric Interview (MINI) 7.0.2 suicidality module
- MRI contraindications such as claustrophobia, ferrous implants, braces, or pacemakers
- Major neurological illness (e.g., self-reported history of organic mental syndromes, head trauma, migraines, seizures, other Central Nervous System (CNS) disease, or other significant medical illness that would make participation unsafe or unfeasible)
- Positive urine toxicology or pregnancy test
- Any disability or health problem that prevents them from completing study procedures (e.g. back problems, severe carpal tunnel syndrome, impaired vision that is not corrected with glasses or contact lenses, etc.).
- Present diagnosis of alcohol use disorder or substance use disorder (moderate or severe)
- Present or previous diagnosis of psychosis, bipolar disorder, or major developmental disorder (autism spectrum disorder, intellectual developmental disorder) based on DSM-5 criteria.
Key Trial Info
Start Date :
May 5 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 24 2024
Estimated Enrollment :
308 Patients enrolled
Trial Details
Trial ID
NCT03451409
Start Date
May 5 2018
End Date
January 24 2024
Last Update
July 26 2024
Active Locations (1)
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1
New York University School of Medicine
New York, New York, United States, 10016