Status:
COMPLETED
MAPD: Modifiable Factors Affecting Propofol Dosing
Lead Sponsor:
Chelsea and Westminster NHS Foundation Trust
Conditions:
Anesthesia
Eligibility:
All Genders
18-65 years
Brief Summary
The investigators aim to understand the effect of a caffeine intake, sleep habits, anxiety about surgery, alcohol intake and smoking status upon the dose of the anaesthetic drug, propofol, required fo...
Detailed Description
The investigators hypothesise that modifiable environmental factors may cause reversible changes in a patients neurobiology which affect their responsiveness to anaesthetic drugs. Such factors may inc...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- ASA I or II patients scheduled for elective day case general anaesthesia with Laryngeal Mask Airway (LMA) airway insertion and a standard propofol-fentanyl induction, aged between 18-65 years at Chelsea \& Westminster Hospital.
- Exclusion Criteria
- Pregnancy
- Neurological disease
- Substance abuse
- Cardiac disease
- Renal disease
- Obesity
- Additional exclusion criteria include:
- Any patient requiring adjunctive analgesia including local/epidural/spinal anaesthesia.
- Any patient requiring an anesthetic induction regime other than propofol-fentanyl (inc. administration of benzodiazepines or other strong opioids).
- Any patient who does not receive a standard anaesthetic induction regime due to clinical need
Exclusion
Key Trial Info
Start Date :
April 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 31 2019
Estimated Enrollment :
91 Patients enrolled
Trial Details
Trial ID
NCT03453099
Start Date
April 1 2018
End Date
August 31 2019
Last Update
February 5 2020
Active Locations (1)
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1
Chelsea and Westminster Hospital
London, United Kingdom, SW109NH