Status:
COMPLETED
Hemofiltration in Acute Ischemic Stroke
Lead Sponsor:
University Medical Center, Kazakhstan
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Ischemic stroke is accompanied by a three to four hundred percent increase in the brain's extracellular fluid (ECF) and cerebrospinal fluid (CSF) concentration of glutamate, which diffuses and damages...
Detailed Description
Ethical Conduct of the Study Investigator Responsibilities The principle investigator was responsible for monitoring and responding to adverse events, ethical participant use, compliance with the pr...
Eligibility Criteria
Inclusion
- 18 to 75 year-old; both males and females;
- Diagnosis of acute ischemic stroke verified by CT or MRI and moderate to severe disability (NIHSS 5-21 points, GCS \> 4 points and \< 12);
- Able to start hemofiltration treatment within 12 hours of stroke onset.;
- Signed written informed consent in either Kazakh or Russian.
Exclusion
- Age below 18 years or above 75 years;
- Presentation over 12 hours from stroke onset;
- Decompensated coronary heart disease (unstable angina, acute myocardial infarction, heart failure - according to New York or Canadian classification, 3, blood disorders, known coagulopathy, platelet count less than75 000 / mmc;
- Pulmonary edema, shock, hemodynamic instability;
- Intracranial hemorrhage or lesions (brain abscess, tumors);
- Inability to obtain informed consent;
- Pregnancy;
- Contraindications for CT.
Key Trial Info
Start Date :
June 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2015
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT03454867
Start Date
June 1 2014
End Date
January 31 2015
Last Update
March 6 2018
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