Status:
COMPLETED
Nitric Oxide Administration During Pediatric Cardiopulmonary Bypass Surgery to Prevent Platelet Activation
Lead Sponsor:
Medical College of Wisconsin
Collaborating Sponsors:
Mallinckrodt
Clinical & Translational Science Institute of Southeast Wisconsin
Conditions:
Inflammation
Platelet Dysfunction
Eligibility:
All Genders
Up to 1 years
Phase:
PHASE2
PHASE3
Brief Summary
Open heart surgery requires the use of a cardiopulmonary bypass (CPB) circuit. As blood flows across the artificial surfaces of the CPB circuit, platelets are activated and consumed. This activation r...
Detailed Description
Open heart surgery requires the use of a CPB circuit. As blood flows across the artificial surfaces of the CPB circuit, platelets are consumed (1). The investigators recently completed a prospective o...
Eligibility Criteria
Inclusion
- Infants less than one year of age
- Undergoing cardiac surgery with the use of cardiopulmonary bypass
Exclusion
- Prior surgery requiring CPB within the same hospitalization
- Pre-operative need for extracorporeal membrane oxygenation or mechanical circulatory support
- Known hypersensitivity to nitric oxide
- Known hemostatic or thrombotic disorder that results in an altered transfusion/anticoagulation protocol
Key Trial Info
Start Date :
April 25 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 5 2019
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03455218
Start Date
April 25 2018
End Date
May 5 2019
Last Update
August 13 2020
Active Locations (1)
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1
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States, 53226