Status:
ACTIVE_NOT_RECRUITING
Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE)
Lead Sponsor:
Baylor College of Medicine
Collaborating Sponsors:
Brown University
University of Pittsburgh
Conditions:
OCD
Obsessive-Compulsive Disorder
Eligibility:
All Genders
21-70 years
Brief Summary
The investigators propose to synchronize automated measurements of behavior - head, body, and face dynamics, gaze, and vocal prosody - with simultaneous recordings of brain activity in clinically rele...
Detailed Description
Baylor College of Medicine (BCM), University of Pittsburgh (UPitt) and Brown University will collaborate on this research project. BCM will be the only site that will enroll study subjects and perform...
Eligibility Criteria
Inclusion
- OCD subjects:
- The subject has a minimum score of ≥16 on the Y-BOCS;
- If applicable, on a stable pharmacologic regimen;
- Sample will be enriched with OCD subjects having contamination obsessions and handwashing compulsions, and scores on items 9 and 10 of the Y-BOCS reflecting difficulty resisting and controlling compulsions;
- Healthy Control Subjects:
- Men and women will be age/gender matched with subjects
- Absence of any psychiatric disorder determined by the MINI\^53 for DSM-5 with the exception of non-impairing specific phobia.
- Low scores on measures of contamination concerns and disgust sensitivity based on Y-BOCS scores below 10 and the Disgust Scale-Revised (total score \<8).
Exclusion
- OCD Subjects:
- Subject has a documented lifetime diagnosis of psychotic disorders such as schizophrenia;
- Alcohol or substance abuse/dependence reported within 6 months, excluding nicotine;
- The subject is deemed at high risk of suicidal behavior or impulsivity. The Beck Depression Inventory\^52 (BDI) will be completed by all subjects and responses reviewed by a clinician.
- Healthy Control Subjects:
- \- Those not meeting the inclusion criteria described in the inclusion section above.
Key Trial Info
Start Date :
June 11 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT03459456
Start Date
June 11 2018
End Date
July 1 2026
Last Update
August 18 2025
Active Locations (3)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15260
2
Brown University
Providence, Rhode Island, United States, 02912
3
Baylor College of Medicine
Houston, Texas, United States, 77030