Status:
COMPLETED
Fecal Microbiota Alterations in Steroid Refractory Active Colitis Ulcerosa
Lead Sponsor:
Medical University of Graz
Conditions:
Colitis, Ulcerative
Eligibility:
All Genders
18+ years
Brief Summary
Alterations in the intestinal microbiota have been associated to disease pathogenesis in ulcerative colitis. Refractory disease to standard medical therapy as corticosteroids often leads to an unfavou...
Detailed Description
The Investigators suggest that certain alterations in the intestinal microbiota are at least in part responsible for the inability of some patients to response to steroid therapy and probably also for...
Eligibility Criteria
Inclusion
- Active ulcerative colitis with a Lichtiger score ≥4
- Patient scheduled for steroid therapy with systemic steroids (prednisolone or methylprednisolone) at standard dosing and patients who started steroid therapy not longer than 48 hours prior to the study inclusion.
- Written informed consent
- Established or suspected diagnosis of ulcerative colitis or indeterminate colitis
Exclusion
- No follow up possible
- Bacterial intestinal infections (C. difficile, Salmonella, EHEC, Campylobacter, Shigella, Yersinia), parasitic or viral infection causing acute infectious diarrhea at baseline.
- Diagnosis of Crohn´s disease
- Planned initiation or discontinuation of probiotic therapy between baseline and follow up visit
Key Trial Info
Start Date :
March 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2021
Estimated Enrollment :
114 Patients enrolled
Trial Details
Trial ID
NCT03460847
Start Date
March 1 2018
End Date
March 1 2021
Last Update
September 8 2021
Active Locations (1)
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1
LKH Graz
Graz, Styria, Austria, 8036