Status:
RECRUITING
Operant Conditioning for Neuromodulation
Lead Sponsor:
Stacey Dejong
Collaborating Sponsors:
Roy J. Carver Charitable Trust
National Center of Neuromodulation for Rehabilitation
Conditions:
Stroke
Healthy
Eligibility:
All Genders
21-90 years
Phase:
NA
Brief Summary
Emerging evidence demonstrates that animals and people can exert control over the level of excitability in spinal and corticospinal neural circuits that contribute to movement. This discovery has impo...
Detailed Description
The purpose of this study is to investigate neuromodulation as new approach to enhance rehabilitation for people who have upper limb movement impairment after neurological injury such as stroke or spi...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Healthy Group:
- Able and willing to provide informed consent
- Normal function of both upper extremities
- Generally in good health
- Exclusion Criteria for Healthy Group:
- Any self-reported disease or disorder that might affect this study, including neurologic, psychiatric, muscular, orthopedic, cardiac, vascular, pulmonary, hematologic, infectious, immune, gastrointestinal, urogenital, integumentary, oncologic, or endocrine conditions
- Any self-reported or demonstrated loss of sensation, passive range of motion, or motor function affecting any part of the upper limb on either side
- Inclusion Criteria for Stroke Group:
- Able and willing to provide informed consent
- Subcortical ischemic stroke OR incomplete spinal cord injury, diagnosed by a neurologist at least 3 months before enrollment
- Upper limb sensorimotor impairment on one or both sides, as indicated by a score of 10 to 56 out of 66 points on the Fugl-Meyer Assessment of the Upper Extremity
- Cognitive ability that is normal or only mildly impaired, as indicated by a score of 9 or less on the Short Blessed Test
- Normal receptive and expressive language abilities, as indicated by a score of 0 on the Best Language item of the National Institutes of Health Stroke Scale
- Exclusion Criteria for Stroke Group:
- Any self-reported or medically documented disease or disorder that might affect this study, including other neurologic conditions besides stroke or spinal cord injury, psychiatric, muscular, orthopedic, cardiac, vascular, pulmonary, hematologic, infectious, immune, gastrointestinal, urogenital, integumentary, oncologic, or endocrine conditions
- Diagnosis of hemorrhagic stroke or hemorrhagic conversion
- Diagnosis of an infarct affecting the motor cortex
Exclusion
Key Trial Info
Start Date :
June 8 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03461159
Start Date
June 8 2018
End Date
June 30 2024
Last Update
January 18 2024
Active Locations (1)
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1
University of Iowa
Iowa City, Iowa, United States, 52242