Status:
UNKNOWN
Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation
Lead Sponsor:
Hospital de Clinicas de Porto Alegre
Conditions:
Sepsis
Eligibility:
All Genders
Phase:
NA
Brief Summary
Due to the failure of the respiratory system, many patients admitted to the Intensive Care Units (ICUs) require the institution of invasive mechanical ventilation (MV), aiming at maintaining gas excha...
Detailed Description
This study aims to evaluate the biomarkers of lung injury in the hyperinflation maneuver with mechanical ventilator versus manual hyperinflation with ambu in septic patients under mechanical ventilati...
Eligibility Criteria
Inclusion
- All patients admitted to the ICPA ICU who have a minimum of 24 hours under mechanical ventilation, coupled to the orotracheal tube (TOT) or tracheostomy (TQT) in pressure-controlled ventilation (PCV) or volume-controlled ventilation (VCV) .
- Hemodynamically stable patients with mean arterial pressure equal to or greater than 60 mmHg with Noradrenaline doses of less than 0.5 μg / kg / minute.
- Septic patients.
Exclusion
- Patients with contraindications to increased positive pressure (non-drained pneumothorax and hemothorax, subcutaneous emphysema).
- Patients with a diagnosis of adult respiratory distress syndrome (ARDS).
- Neurosurgical patients who are under intracranial pressure monitoring (ICP);
- Patients with Peak inspiratory pressure (PIP) = 40 cmH2O and / or PEEP\> 10 cmH2O.
- Post-surgical patients
- Patients submitted to extracorporeal circulation (ECC)
- Chronic renal patients
- Patients without relatives.
Key Trial Info
Start Date :
March 23 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 20 2019
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03464071
Start Date
March 23 2018
End Date
December 20 2019
Last Update
July 31 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90035903