Status:
ACTIVE_NOT_RECRUITING
A First in Human Study Using 89Zr-cRGDY Ultrasmall Silica Particle Tracers for Malignant Brain Tumors
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Conditions:
Brain Cancer
Pituitary Adenoma
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this study is to test if PET scans using 89Zr-DFO-cRGDY-PEG-Cy5-C' dot particles, can be used to take pictures of brain tumors. The investigators want to understand how the particles ar...
Eligibility Criteria
Inclusion
- 18 years of age or older
- Histologically confirmed diagnosis of malignant primary brain tumor clinical and radiographic findings consistent with a pituitary adenoma, or known metastatic cancer with brain lesion presumed to be metastatic.
- Normal baseline cardiac function based upon pre-operative evaluation at the physcian's discretion
- All patients of childbearing age must use an acceptable form of birth control
- Women who are pre-menopausal must have a negative serum pregnancy test
Exclusion
- Known pregnancy or breast-feeding Medical illness unrelated to the tumor which in the opinion of the attending physician and principal investigator will preclude administration of the tracer
- °This includes patients with uncontrolled infection, chronic renal insufficiency, myocardial infarction within the past 6 months, unstable angina, cardiac arrhythmias other than chronic atrial fibrillation and chronic active or persistent hepatitis, or New York Heart Association Classification III or IV heart disease
- More than one metastatic cancer active in the last 5 years
- Active metastatic cancer in addition to malignant primary brain tumor
- Weight greater than the 400-lb weight limit of the PET scanner
- Unmanageable claustrophobia
- Inability to lie in the scanner for 30 minutes
Key Trial Info
Start Date :
March 7 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2026
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT03465618
Start Date
March 7 2018
End Date
March 1 2026
Last Update
January 7 2026
Active Locations (1)
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1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065