Status:
COMPLETED
miRNAs Profiling in Parkinson's Disease
Lead Sponsor:
Neuromed IRCCS
Conditions:
Parkinson Disease
Eligibility:
All Genders
30+ years
Brief Summary
microRNAs (miRNAs) regulate fundamental cell processes. Dysregulation of miRNA expression and function is reported in various diseases including cancer, metabolic disorders as well as neurological dis...
Detailed Description
Hypothesis and Significance: The project intends to identify novel biomarkers for PD and clinical parameters related to the PD etiology. To do that circulating miRNA profiling through a next-generati...
Eligibility Criteria
Inclusion
- Inclusion Criteria for cases:
- Presence of at least two out the following cardinal signs: resting tremor, cogwheel rigidity, bradykinesia, asymmetrical onset of symptoms and symptomatic response to L-dopa (levodopa)
- Exclusion Criteria for cases:
- Previous thalamotomy on the implanted sided, significant brain atrophy or structural damage seen on CT or MRI, marked cognitive dysfunction, active psychiatric symptoms, or concurrent neurological or other uncontrolled medical disorders.
- Exclusion Criteria for controls:
- Personal or family history for neurodegenerative diseases
Exclusion
Key Trial Info
Start Date :
February 14 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 14 2022
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT03466723
Start Date
February 14 2019
End Date
June 14 2022
Last Update
March 23 2023
Active Locations (1)
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1
Neuromed IRCCS
Pozzilli, Molise, Italy, 86077