Status:
UNKNOWN
Role of NLRP3 Inflammasone and Hypoxia in the Severity of Osteoporosis in Patients With Bronchiectasis
Lead Sponsor:
Chun-Hua Wang, MD
Conditions:
Bronchiectasis Adult
Osteoporosis, Osteopenia
Eligibility:
All Genders
20+ years
Brief Summary
The objectives of this research grant are to determine the association of hypoxia with the severity of osteoporosis in the patients with bronchiectasis and whether the mechanism of inflammation is tri...
Detailed Description
80 patients with proven bronchiectasis, diagnosed by high-resolution computed tomography (HRCT), will be recruited from our outpatient clinic of Chang Gung Memorial Hospital with written informed cons...
Eligibility Criteria
Inclusion
- willing to sign a written consent form
- Male and female subjects with bronchiectasis diagnosed by high-resolution computed tomography
- willing to accept 6-minute exercise pulmonary function test and blood draw
- Men and women over the age of 20
- Has undergone chest computed tomography and bone density examination in the recent five years
Exclusion
- pregnant women or lactating women
- asthma, lung resection history before the screening period
- active Tuberculosis infection
- Have received oral steroid treatment within 30 days
- current acute attack or clinical symptoms instability of bronchiectasis
Key Trial Info
Start Date :
December 21 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2019
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03467035
Start Date
December 21 2017
End Date
June 30 2019
Last Update
March 15 2018
Active Locations (1)
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1
Chang Gung Memorial Hospital
Taipei, Taiwan, 333