Status:
COMPLETED
The Effect of Dietary Nitrate on the Oral Microbiome
Lead Sponsor:
University of Exeter
Conditions:
Cardiovascular Health
Identify Oral Bacteria Responsible for Nitrate Reduction
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This study evaluates whether dietary manipulation of the oral microbiota modulates cardiovascular health through effects on nitric oxide bioavailability.
Detailed Description
Nitric oxide is an important molecule for human health because it controls blood flow and blood pressure. With aging, our ability to make nitric oxide gets worse and our blood pressure tends to increa...
Eligibility Criteria
Inclusion
- Healthy young (18-30 yr) and older adults (65-80 yr)
- Male and female
- Willing to undergo the experiments as detailed in the informed consent documentation
- Willing and capable of providing written, informed consent.
Exclusion
- Individuals receiving medication for pulmonary, cardiovascular, or metabolic conditions, ulcerative colitis or renal disease
- Having an active oral disease or dentures
- Having resting BP \>140/90 mmHg
- Having used antibiotics within 3 months
- Lacking willingness or capacity to give informed consent.
Key Trial Info
Start Date :
January 10 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 6 2021
Estimated Enrollment :
101 Patients enrolled
Trial Details
Trial ID
NCT03467061
Start Date
January 10 2018
End Date
May 6 2021
Last Update
May 27 2021
Active Locations (1)
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1
Diabetes & Vascular Medicine Research Centre, Clinical Research Facility
Exeter, Devon, United Kingdom