Status:
UNKNOWN
Mental Stress & Diesel Exhaust on Cardiovascular Health
Lead Sponsor:
University of Washington
Collaborating Sponsors:
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Blood Pressure
Inflammation
Eligibility:
All Genders
22-49 years
Phase:
NA
Brief Summary
This study uses an experimental design to conduct a double-blind, randomized, crossover study where participants receive both diesel exhaust and a mental stress test in a controlled setting. My hypoth...
Eligibility Criteria
Inclusion
- Non-smokers without history of high blood pressure, asthma, diabetes, high cholesterol, post-traumatic stress disorder (PTSD) or any other chronic condition that requires ongoing care.
Exclusion
- Smoking: We rule out active smoking by checking urine cotinine during our study.
- History of high blood pressure: We objectively measure BP during in-person screening and exclude those with blood pressure (\>130/85 mmHg).
- Asthmatic: Spirometry is done at screening to rule out asthma.
- Diabetic: We obtain fasting blood sugar to rule out diabetes at screening (\>125 mg/dL)
- Cholesterol: We obtain fasting blood lipid levels to rule out hypercholesterolemia at screening (\>200 mg/dL).
- History of PTSD: Subjects will be asked about prior PTSD diagnosis during the phone and in person screen.
- Any other chronic condition requiring ongoing care based on medication use.
- A body mass index (weight in kilograms divided by height in meters squared) greater than 26 and less than 18.5
- A female of childbearing age with a positive pregnancy test
- A female of childbearing age who is unwilling to use effective contraception during the study
Key Trial Info
Start Date :
March 22 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2020
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT03467997
Start Date
March 22 2018
End Date
January 1 2020
Last Update
November 5 2018
Active Locations (1)
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1
University of Washington Diesel Exhaust Facility
Seattle, Washington, United States, 98195