Status:
COMPLETED
Perioperative Research Into Memory: Cognitive Outcome Following Major Burns
Lead Sponsor:
Chelsea and Westminster NHS Foundation Trust
Collaborating Sponsors:
Imperial College Healthcare NHS Trust
University of Westminster
Conditions:
Major Injury
Eligibility:
All Genders
16+ years
Brief Summary
The long term survival of patients who require admission to critical care (CC) following a major burn injury (MBI) continues to improve with advanced clinical management. There has been increasing int...
Detailed Description
This is a novel, proof of principle, prospective, cohort design, observational clinical study to assess for functional brain reorganisation, structural changes and long-term cognitive dysfunction foll...
Eligibility Criteria
Inclusion
- Survival following admission to Chelsea and Westminster Burns Intensive Care Unit between 2004-2013 with a burn injury \> 15% total body surface area, requiring intubation and ventilation
Exclusion
- Patients under 16.
- Patients with toxic epidermal necrolysis syndrome or evidence of head trauma.
- Patients with evidence of risk to psychological safety from inclusion in study: any patient currently held under section of the Mental Health Act, any patient receiving formal psychiatric treatment (including involvement in a Personality Disorder Unit, being under voluntary section, current re-occurrence of chronic self harm), any patient currently detained at her Majesty's pleasure, any current substance abuse, or at the discretion of professional opinion following historical assessment of notes. - Patients with contraindications to MRI (patients with non-compatible pacemakers, patients with metallic foreign bodies e.g. metal sliver in their eye, patients with non-compatible surgical metal work, patients with severe claustrophobia).
- Patient refusal or inability to give full informed consent.
- Patients unable to understand plain verbal or written English.
Key Trial Info
Start Date :
August 5 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 30 2017
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT03470844
Start Date
August 5 2015
End Date
October 30 2017
Last Update
March 20 2018
Active Locations (1)
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1
The Burn Intensive Care Unit (BICU), Chelsea and Westminster Hospital
London, United Kingdom, SW10 9NH