Status:
WITHDRAWN
Exploration of the Enteric Nervous System in Alzheimer Disease
Lead Sponsor:
Nantes University Hospital
Conditions:
Alzheimer Disease
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
The close homology between the central and enteric nervous system suggests that a disease process affecting the central nervous system could also involve its enteric counterpart. This has already been...
Detailed Description
The close homology between the central and enteric nervous system suggests that a disease process affecting the central nervous system could also involve its enteric counterpart. The investigators hav...
Eligibility Criteria
Inclusion
- For the 3 groups of patients : colonoscopy planned by a gastroenterologist in the context ot the usual medical follow-up of the patient
- For patients with Alzheimer's disease :
- Patient with early to moderate Alzheimer disease (continuum of patients with mild cognitive impairment due to Alzheimer's disease and patients diagnosed with probable Alzheimer's disease) according to the National Institute of Aging-Alzheimer's Association (NIA AA) criteria
- Mini-Mental State Examination (MMSE) score ≥18;
- Has one informant or care partner;
- No parkinsonian syndrome
- No sign of lewy Body dementia
- For patients with Parkinson's disease:
- patients with Parkinson Disease according to the United Kingdom Parkinson's Disease Society Brain Bank (UKPDSBB) criteria
- No dementia sign or cognitive deficit associated to Alzheimer's disease
- For patients without neurodegenerative disease:
- No history or current neurological/degenerative condition (e.g, lewy body dementia, Parkinson's disease, Parkinsonian syndrome, Alzheimer's disease,…)
- No memory complaint with a Mac Nair score ≤15
- MMSE score ≥28 ;
- Patient at risk of colic cancer with a colonoscopy scheduled
Exclusion
- For the 3 groups of patients : :
- History of colonic disorder ((e.g inflammatory condition, adenocarcinoma)
- contra-indications to colonoscopy
- For patients with Alzheimer's disease and for patients with Parkinson's disease:
- \- Any neurological/neurodegenerative condition different from the group to which it belongs (e.g other than Alzheimer's disease for Alzheimer's disease group or other than Parkinson's disease for Parkinson's disease group….)
- For patients without neurodegenerative disease:
- Any neurological/neurodegenerative condition (e.g lewy body dementia, Parkinsonian syndrome, Parkinson's disease, Alzheimer's disease..)..
- functional colopathy
Key Trial Info
Start Date :
April 26 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 18 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03472183
Start Date
April 26 2018
End Date
September 18 2019
Last Update
April 1 2020
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