Status:
UNKNOWN
Optical Coherence Tomography in Cerebral Amyloidosis
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Conditions:
Alzheimer Disease
Dementia Alzheimers
Eligibility:
All Genders
Brief Summary
In this observational study, the investigators aim to evaluate whether changes in the retinal and choroidal circulation, as assessed by Optical Coherence Tomography (OCT) and the quantification of ret...
Detailed Description
Being a direct extension of the central nervous system and the only place in the human body where the vessels of the central circulation can be visualized directly, the eye provides a unique window to...
Eligibility Criteria
Inclusion
- Cognitively intact healthy controls will be recruited from an ongoing community-recruited longitudinal cohort of cognitively intact older adults (55-85 years, S51125) who all have undergone amyloid Positron Emission Tomography (PET) at the baseline visit in the context of study S51125. Half of the subjects will be amyloid-positive and half will be amyloid-negative. In the context of study S51125 these subjects receive two-yearly neuropsychological assessment.
- MCI patients (Petersen et al., 2004 criteria) will be recruited from an ongoing memory-clinic recruited longitudinal cohort of patients with amnestic mild cognitive impairment who participate in study S55892. All subjects have undergone an amyloid PET at the baseline study in the context of study S55892. Half of the subjects will be amyloid-positive and half will be amyloid negative.
- Clinically probable AD subjects (National Institute of Neurological Disorders and Stroke (NINDS) and the Association Internationale pour la Recherche et l'Enseignement en Neurosciences (AIREN) criteria) will be recruited from the memory clinic University Hospitals Leuven (MMSE 12-28). Subjects will be recruited only if they are capable of providing written informed consent.
- Clinically probable LBD (McKeith et al. criteria, 2005) will be recruited from the memory clinic University Hospitals Leuven (MMSE 12-28). Subjects will be recruited only if they are capable of providing written informed consent.
- Capable and willing to participate
Exclusion
- Personal medical history of retinal neovascularization
- Unable or unwilling to give consent
Key Trial Info
Start Date :
March 25 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2019
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT03472482
Start Date
March 25 2016
End Date
December 31 2019
Last Update
March 21 2018
Active Locations (1)
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1
UZ Leuven
Leuven, Belgium, 3000