Status:
COMPLETED
Brain BOLD fMRI in Hypertensive and Normotensive Participants
Lead Sponsor:
Centre Hospitalier Universitaire Vaudois
Collaborating Sponsors:
Ecole Polytechnique Fédérale de Lausanne
Conditions:
Hypertension,Essential
Eligibility:
All Genders
18+ years
Brief Summary
This study will explore the brainstem activity in response to stress in hypertensive patients and normotensive subjects. In addition, it will evaluate if the response in hypertensive patients can be m...
Detailed Description
In hypertension, the overactivity of the sympathetic nervous system (SNS) has been found to be implicated in its initiation, maintenance and adverse consequences. The SNS is composed of an afferent an...
Eligibility Criteria
Inclusion
- signed informed consent
- capable of discernment
Exclusion
- having contra-indications for MRI (claustrophobia, cardiac pacemaker or other metallic or mechanical implant or device, etc.)
- pregnant women
- lower limb sensitive neuropathy
- Blood pressure \>180/110 mmHg during washout period (for hypertensive patients)
- Intolerance to Sonovue®(ultrasound contrast agent)
- Acute or chronic disease other than hypertension that influences renal function
- taking medication/drugs, except of calcium channel blockers for resistant hypertensive patients
Key Trial Info
Start Date :
August 16 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 12 2022
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT03473275
Start Date
August 16 2018
End Date
August 12 2022
Last Update
February 21 2023
Active Locations (1)
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1
CHUV, nephrology service
Lausanne, Canton of Vaud, Switzerland, 1011