Status:
TERMINATED
Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation
Lead Sponsor:
St. Joseph's Hospital and Medical Center, Phoenix
Conditions:
Cerebral Cavernous Malformations
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This is a single center, randomized, trial that will enroll twenty (n=20) patients with a diagnosis of symptomatic cavernous malformations who are planned candidates for surgical resection by one of t...
Detailed Description
This is a single center, randomized, trial that will enroll twenty (n=20) patients with a diagnosis of symptomatic cavernous malformations who are planned candidates for surgical resection by one of t...
Eligibility Criteria
Inclusion
- Subject is at least 18-years of age.
- Clinical and imaging diagnosis of a symptomatic Isolated cavernous malformation or Familial cavernous malformation
- MRI Imaging Grade Type I or Type II (see Table 1)
- Patient is considered a candidate for surgical resection of their cavernous malformation
- Written and informed consent obtained prior to the study enrollment.
- Negative pregnancy test at time of enrollment for women of child-bearing potential.
- Heart rate greater than 50 beats per minute
- Systolic blood pressure \> 90 mmHg
Exclusion
- Subject is less than 18-years of age.
- History of allergy to propranolol or other beta blockers.
- Patient is already taking another beta blocker for cardiac indications.
- History of asthma presently requiring any active treatment (oral medications or inhalers).
- History of cardiac dysfunction (as defined by the New York Heart Association Functional Classification grade II, III or IV).
- Heart rate \< 50 beats per minute
- Systolic blood pressure \< 90 mmHg
- History of diabetes and currently on any anti-hyperglycemic medication.
- Pregnant and lactating women.
Key Trial Info
Start Date :
January 24 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 11 2021
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT03474614
Start Date
January 24 2018
End Date
February 11 2021
Last Update
April 19 2024
Active Locations (1)
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1
Barrow Neurological Institute
Phoenix, Arizona, United States, 85013